University of Maryland, Baltimore · Microbiology & ImmunologyFlajnik Immunology Lab
Martin F Flajnik · Baltimore, Maryland
Research Focus
Dr. Martin Flajnik's lab focuses on understanding the evolution and function of the immune system, particularly how it has developed over millions of years. By studying sharks, which possess unique immune molecules, the lab aims to uncover foundational principles of immunity that may also apply to humans. The research combines biochemistry, structural biology, and immunological techniques to explore how these ancient immune components operate and their implications for human health.
adaptive immunityMHCshark immunologynonclassical class I moleculesantigen recognition
Research Aims
5AIM 01Determine the structure and function of shark nonclassical class I molecules UDA and UFA.
AIM 02Investigate the biochemical pathways involved in UDA/UFA biosynthesis.
AIM 03Characterize the immune response mediated by shark UDA and UFA molecules.
AIM 04Examine the expression patterns of UDA and UFA under stress conditions in shark cells.
AIM 05Explore the evolutionary significance of nonclassical MHC molecules in ancient immune systems.
Skills the Lab Values
PCRcell cultureX-ray crystallographyantibody productionin situ hybridizationbiochemical analysisnanobody generationprotein purificationflow cytometrysingle-cell analysis
Output against the department
Publications236top 25% of dept.123rd of 486
this lab
most publishedleast published
Citations15ktop 26% of dept.126th of 486
this lab
most citedleast cited
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