University of California-Irvine · BiochemistryThe Ubiquitin Nexus
Peter Kaiser · Irvine, California
Research Focus
Dr. Peter Kaiser’s lab at UC Irvine studies two major areas: how cells communicate environmental signals through ubiquitin signaling and the reactivation of mutant p53 proteins in cancer. By examining metabolism and its effects on the cell cycle, as well as developing therapies for cancer that target p53, the lab aims to uncover important mechanisms underlying cell growth, disease, and potential treatments.
ubiquitin signalingp53 reactivationmetabolite signalingcancer therapycell proliferationmethionine metabolismprotein interactionsRNA methylationtherapeutic development
Research Aims
5AIM 01Investigate how different ubiquitin chain types are recognized by cellular machinery.
AIM 02Study the role of methionine metabolism in the control of cell proliferation.
AIM 03Understand how p53 mutations affect cancer cell behavior and potential reactivation.
AIM 04Develop pharmacological agents that can restore function to mutant p53 proteins.
AIM 05Explore the mechanisms connecting cellular metabolism with mRNA translation efficiency.
Skills the Lab Values
molecular biology techniquescell cultureyeast model systemsmammalian cell line experimentsproteomic profilingWestern blotRNA sequencingdrug compound designapoptosis assays
Output against the department
Publications769top 4% of dept.16th of 402
this lab
most publishedleast published
Citations40ktop 6% of dept.26th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.