University of Pennsylvania · BiologyYang Lab
Xiaolu Yang · Philadelphia, Pennsylvania
Research Focus
Dr. Xiaolu Yang's lab at the University of Pennsylvania focuses on understanding how specific proteins affect the development and progression of neurodegenerative diseases like ALS and FTD. They investigate the roles of unique proteins involved in maintaining the stability and function of other proteins in the cell, particularly regarding protein aggregation, which is a key feature in many diseases. Their research aims to explore potential therapeutic strategies to combat these conditions by enhancing our understanding of protein quality control mechanisms in cells.
TDP-43FUSneurodegenerative diseasesprotein quality controlTRIM proteins
Research Aims
5AIM 01Identify the role of TRIM11 in regulating TDP-43 and FUS proteins
AIM 02Elucidate the mechanisms by which TRIM proteins prevent protein aggregation
AIM 03Evaluate the implications of p53 in regulating cellular processes related to cancer
AIM 04Investigate the role of ERK signaling in cancer progression
AIM 05Explore therapeutic targets related to protein misfolding diseases.
Skills the Lab Values
Cell cultureMolecular cloningRNA sequencingWestern blottingImmunofluorescenceProtein purificationMouse modelsBiochemical assays
Output against the department
Publications104bottom 36% of dept.657th of 1,033
this lab
most publishedleast published
Citations12ktop 31% of dept.322nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.