University of Utah · BiochemistryTRIM Protein Interaction Lab
Owen Pornillos · Salt Lake City, Utah
Research Focus
Dr. Owen Pornillos' lab focuses on understanding how certain proteins called TRIM5 proteins protect cells against viruses like HIV. They study the structure of these proteins and how they interact with viral components to prevent infection. Through advanced techniques, their research aims to uncover the details of how TRIM5 proteins function, which could lead to new ways to combat HIV/AIDS.
TRIM proteinsHIVviral inhibitionstructure biologyinnate immunity
Research Aims
3AIM 01Extend the resolution of the TRIM5a/capsid superlattice structure.
AIM 02Utilize in vitro systems to study TRIM5's mechanism of deactivation of viral cores.
AIM 03Investigate the role of TRIM34 in enhancing TRIM5a's activity against HIV-1.
Skills the Lab Values
X-Ray CrystallographyCryoelectron Microscopycell-free system reconstitutionubiquitinationprotein engineering
Output against the department
Publications97bottom 23% of dept.308th of 402
this lab
most publishedleast published
Citations7.6kbottom 41% of dept.236th of 402
this lab
most citedleast cited
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