Harvard University · Microbiology & ImmunologyMalaria Resistance and Genomics Unit
Manoj T Duraisingh · Cambridge, Massachusetts
Research Focus
Dr. Manoj T. Duraisingh's lab focuses on understanding malaria, specifically how the malaria parasite Plasmodium vivax becomes resistant to antimalarial drugs and how it interacts with red blood cells. They conduct research to identify genetic factors that contribute to drug resistance and the ability of the parasite to invade different types of red blood cells, which is crucial for designing better treatments and control strategies against this disease.
Plasmodium vivaxmalariadrug resistancegenomicshost cell interactionforward geneticsmolecular determinantspublic healthparasite evolutionantimalarials
Research Aims
5AIM 01Identify genetic determinants of chloroquine resistance in Plasmodium vivax.
AIM 02Analyze drug-resistance polymorphisms using Plasmodium knowlesi as a model.
AIM 03Investigate the molecular basis of host cell tropism in Plasmodium falciparum.
AIM 04Characterize polymorphisms that enable Plasmodium to invade red blood cells of different ages.
AIM 05Develop strategies to monitor and prolong the effectiveness of antimalarial drugs.
Skills the Lab Values
PCRgenetic screeningin vitro cultureforward geneticsreverse geneticsgenomic analysismolecular cloningcell culturetransfection techniques
Output against the department
Publications244top 24% of dept.118th of 486
this lab
most publishedleast published
Citations14ktop 27% of dept.132nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.