Stanford University · BiologyMetabolic Harmony Lab
Jonathan Z Long · Stanford, California
Research Focus
Jonathan Z Long's lab at Stanford University focuses on understanding how different types of metabolites, particularly ketone bodies and lactate, influence energy balance and metabolism in the body. They investigate specific biochemical pathways and how metabolic tissues communicate to maintain healthy function. The research aims to identify novel treatments for obesity and metabolic disorders by studying these metabolic signals and their interactions.
ketone bodieslactate metabolismenergy balancemetabolic tissue crosstalkobesitydiabeteschemical interrogationmetabolite signalingpolypeptide secretomes
Research Aims
5AIM 01Identify the role of the BHB shunt in energy balance.
AIM 02Examine how lactate-derived metabolites affect feeding and obesity.
AIM 03Map the secretomes of various metabolic tissues to understand crosstalk.
AIM 04Develop new methodologies for studying tissue crosstalk in living organisms.
AIM 05Investigate ion channel interactions with BHB-amino acids.
Skills the Lab Values
mouse modelsgene knockout techniquesbiochemical assaysconfocal microscopymetabolomicsflow cytometrycell culturein vivo chemical labelingproteomic analysision channel studies
Output against the department
Publications139top 50% of dept.513th of 1,033
this lab
most publishedleast published
Citations17ktop 24% of dept.244th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.