Tufts University · NeuroscienceAstrocyte Dynamics Research Group
Yongjie Yang · Medford, Massachusetts
Research Focus
Dr. Yongjie Yang's lab at Tufts University studies the role of glial cells in neurodevelopmental and neurodegenerative diseases. Specifically, they investigate how astrocytes, a type of glial cell, contribute to conditions like Fragile X Syndrome and Alzheimer's Disease. The research focuses on understanding the molecular mechanisms influencing behavior and immune responses in these diseases.
Fragile X SyndromeAlzheimer's DiseaseastrocytesmicroRNAsneuroinflammationimmune responseexosomesCNS pathogenesis
Research Aims
4AIM 01Determine the roles of microRNA-128 in regulating postnatal astroglial development
AIM 02Investigate the pathogenic impact of increased astroglial microRNA-128 in Fragile X Syndrome
AIM 03Examine the efflux of CNS-derived exosomes in Alzheimer's disease models
AIM 04Identify the antigenicity of astroglial exosomes in activating T cells during Alzheimer's disease
Skills the Lab Values
mouse geneticsprimary astroglial cultureselectrophysiologyimmunohistochemistrytwo-photon imagingvirus injectionsflow cytometrybiochemical assaysbehavioral phenotyping
Output against the department
Publications110bottom 38% of dept.411th of 671
this lab
most publishedleast published
Citations3.9kbottom 30% of dept.472nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.