University of Nebraska Medical Center · NeuroscienceFox Neurobiology Lab
Howard S Fox · Omaha, Nebraska
Research Focus
Dr. Howard Fox's lab focuses on understanding how HIV and opioid use affect the brain on a cellular level. They use advanced techniques like single-cell RNA sequencing to examine how these factors interact and influence various brain cells. This research helps uncover important information about the neurological implications of HIV and drug abuse, with the potential to improve treatments and outcomes for affected individuals.
HIVOpioid abuseSingle-cell RNA sequencingEpigeneticsNeuroinflammationMicrogliaCNSSIV modelChronic drug exposure
Research Aims
5AIM 01Investigate the effects of HIV on brain cells using single-cell RNA sequencing.
AIM 02Examine how opioid use impacts cellular responses in the context of HIV.
AIM 03Assess the epigenetic changes in brain cells due to HIV and drug exposure.
AIM 04Understand the role of microglia in HIV neuropathogenesis.
AIM 05Develop novel insights for potential interventions to prevent brain damage from HIV and drugs.
Skills the Lab Values
Single-cell RNA sequencing (scRNAseq)Chromatin accessibility assaysMicroglia isolationCell culture techniquesViral quantification assaysImmunohistochemistryIn situ hybridizationData analysis and interpretationExperimental designPower analysis
Output against the department
Publications346top 19% of dept.129th of 671
this lab
most publishedleast published
Citations19ktop 23% of dept.151st of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.