George Washington University · Microbiology & ImmunologyChronic Infection Immunology Lab
Imtiaz Ahmed Khan · Washington, District of Columbia
Research Focus
Dr. Imtiaz Ahmed Khan's lab at George Washington University studies how a type of immune cell, CD4 T cells, becomes less effective during chronic infections like toxoplasmosis. They investigate the molecular mechanisms that lead to CD4 T cell exhaustion and how restoring their function could improve immunity against infections. Their research aims to develop therapies that enhance immune responses in people with weakened immune systems, particularly those suffering from conditions like HIV.
toxoplasmosisCD4 T cellsCD8 T cellsimmune exhaustionepigeneticscostimulatory moleculeschronic infectiontherapeuticsimmunocompromised
Research Aims
4AIM 01Identify the chromatin accessible sites that BLIMP-1 binds to in CD4 T central memory cells.
AIM 02Define the epigenetic changes that lead to CD4 T cell exhaustion during latent toxoplasmosis.
AIM 03Evaluate the role of co-stimulatory molecules in restoring CD4 T cell function after BLIMP-1 ablation.
AIM 04Investigate whether agonist treatments for co-stimulatory molecules can enhance CD8 T cell responses.
Skills the Lab Values
flow cytometrycell culturemouse modelschromatin accessibility assaysgenetic manipulationRT-PCRdata analysisimmunological assaysprotein expression analysis
Output against the department
Publications114bottom 43% of dept.278th of 486
this lab
most publishedleast published
Citations1.8kbottom 12% of dept.430th of 486
this lab
most citedleast cited
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