Case Western Reserve University · PhysiologyNeurodegeneration and Mitochondrial Health Lab
Xin Qi · Cleveland, Ohio
Research Focus
Dr. Xin Qi's lab focuses on understanding the underlying mechanisms of neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD). The lab investigates proteins that influence neuronal health, mitochondrial function, and lipid metabolism, aiming to identify new therapeutic targets that could lead to effective treatments. Overall, their research strives to uncover how disruptions in these processes contribute to disease progression and cognitive deficits.
Alzheimer's diseaseTDP43amyotrophic lateral sclerosismitochondrial dysfunctionoligodendrocytes
Research Aims
3AIM 01Identify the causes and consequences of ATAD3A loss in TDP43-associated ALS/FTD models.
AIM 02Assess whether ATAD3A replacement reduces motor neuron toxicity in ALS/FTD models.
AIM 03Determine the role of CHCHD6 in Alzheimer's disease pathology and its potential for therapeutic intervention.
Skills the Lab Values
cell culturemouse modelsproteomicsgene expression analysisRNA sequencing
Output against the department
Publications228top 27% of dept.76th of 286
this lab
most publishedleast published
Citations13ktop 22% of dept.63rd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.