Icahn School of Medicine at Mount Sinai · Microbiology & ImmunologyViral Adaptation Lab
Adolfo Garcia-Sastre · New York, New York
Research Focus
Dr. Adolfo Garcia-Sastre's lab at the Icahn School of Medicine focuses on studying how viruses, particularly SARS-CoV-2 and other coronaviruses, adapt to human hosts. By utilizing systems biology approaches and advanced modeling techniques, the lab aims to uncover biological networks that influence viral replication and disease severity. Their research seeks to identify potential biomarkers and therapeutic targets that can help in predicting disease outcomes and developing new treatments.
SARS-CoV-2systems biologyviral adaptationhost-virus interactionsbiomarker identification
Research Aims
5AIM 01Investigate host networks that regulate SARS-CoV replication and disease outcomes.
AIM 02Identify biomarkers that predict severity of COVID-19 and other coronavirus infections.
AIM 03Explore virus-host interaction networks responsible for changes in tropism from bats to humans.
AIM 04Develop predictive models for virus pathogenesis and therapeutic interventions.
AIM 05Integrate multi-OMICS data to uncover potential clinical targets for treatment.
Skills the Lab Values
PCRcell cultureanimal modelsmachine learningbioinformaticsproteomicsepigeneticsgenetic screeningomics data analysis
Output against the department
Publications1,142top 1% of dept.4th of 486
this lab
most publishedleast published
Citations105ktop 1% of dept.6th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.