University of Arkansas for Medical Sciences · PharmacologyEicosanoid Regulation Lab
John D Imig · Little Rock, Arkansas
Research Focus
Dr. John D Imig's lab studies how certain molecules in the body, called epoxyeicosatrienoic acids (EETs), can help regulate blood flow and kidney function. They focus on how kidney damage, caused by things like lack of blood flow or blockages, can lead to long-term health issues like high blood pressure and chronic kidney disease. The lab uses techniques in genetics and pharmacology to explore how increasing levels of EETs can potentially prevent or restore kidney function and protect against high blood pressure.
epoxyeicosatrienoic acidskidney injuryblood pressure regulationendothelial dysfunctionchronic kidney disease
Research Aims
3AIM 01Identify the role of decreased EET levels in salt-sensitive hypertension and chronic kidney disease.
AIM 02Investigate how increasing EET levels can improve endothelial function after kidney injury.
AIM 03Evaluate pharmacological strategies to raise EET levels and prevent long-term kidney damage.
Skills the Lab Values
pharmacological manipulationgenetic manipulationcell cultureanimal modelsmeasuring renal blood flowassessing endothelial function
Output against the department
Publications427top 14% of dept.63rd of 462
this lab
most publishedleast published
Citations16ktop 23% of dept.106th of 462
this lab
most citedleast cited
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