University of Iowa · NeuroscienceThe Neurodegeneration Lab
Georgina Aldridge · Iowa City, Iowa
Research Focus
Dr. Georgina Aldridge's lab at the University of Iowa focuses on understanding dementia, particularly Lewy-Body dementia, and how protein aggregates like alpha-synuclein affect brain function. The research examines the impacts of these proteins on neuronal activity and cognitive functions, with the goal of finding potential treatment strategies. The lab also explores how different protein co-pathologies contribute to cognitive decline, utilizing human autopsy samples to gather insights into neurodegeneration.
Lewy-Body DementiaAlpha-SynucleinNeuronal PlasticityCognitive FunctionProtein Co-PathologiesAlzheimer's DiseaseNeurodegenerationDendritic SpinesCortical Activity
Research Aims
3AIM 01Investigate the effect of alpha-synuclein on neuronal activity in the cortex.
AIM 02Examine synaptic plasticity in response to alpha-synuclein aggregation over aging.
AIM 03Identify the relationship between peripheral and brain pathology in dementia cases.
Skills the Lab Values
2-photon microscopyviral overexpression techniquesGolgi stainingimmunofluorescenceunbiased stereologyneuroscience methodologieshuman autopsy sample analysisbehavioral testing in learning tasksdata analysis in neuroimaging
Output against the department
Publications52bottom 11% of dept.593rd of 671
this lab
most publishedleast published
Citations1.8kbottom 10% of dept.602nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.