University of Michigan-Ann Arbor · Microbiology & ImmunologyRASA1 Vascular Dynamics Lab
Philip D King · Ann Arbor, Michigan
Research Focus
Dr. Philip D. King's lab at the University of Michigan focuses on understanding how a specific protein, RASA1, regulates blood vessel development. They study how mutations in this protein can lead to serious vascular malformations in the brain, especially in children. By exploring the molecular mechanisms behind these conditions, the lab aims to find ways to prevent and treat such disorders.
RASA1vascular developmentcerebrovascular malformationsRas signalinggene mutation
Research Aims
3AIM 01Investigate the enzymatic mechanism by which the C2 domain enhances RASA1 function.
AIM 02Analyze mutant mouse models to study vascular defects caused by RASA1 mutations.
AIM 03Conduct experiments to understand the interaction between RASA1 and Ras, and its implications for vascular health.
Skills the Lab Values
mouse modelsenzymatic assaysstructural analysismolecular cloningprotein purification
Output against the department
Publications110bottom 41% of dept.288th of 486
this lab
most publishedleast published
Citations4.5kbottom 35% of dept.318th of 486
this lab
most citedleast cited
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