Icahn School of Medicine at Mount Sinai · NeuroscienceThe Autophagy Nexus
Zhenyu Yue · New York, New York
Research Focus
Dr. Zhenyu Yue's lab at the Icahn School of Medicine focuses on understanding how autophagy helps protect neurons in the brain. They study how the process of autophagy, which recycles damaged cellular components, can go wrong in diseases like Alzheimer's and Parkinson's. The lab aims to discover ways to improve neuroprotection through understanding these mechanisms, potentially leading to new treatments for neurodegenerative diseases.
autophagyneurodegenerative diseasessynucleinopathiesAlzheimer's diseaseParkinson's diseasemicroglianeural protectioncellular recyclingneuron typesproteomics
Research Aims
5AIM 01Elucidate neuroprotective mechanisms of autophagy in neurons.
AIM 02Identify distinct autophagy pathways in different neuron types.
AIM 03Characterize neuronal and microglial autophagy under various conditions.
AIM 04Explore the relationship between autophagy and synaptic vesicle trafficking.
AIM 05Develop therapeutic strategies targeting autophagy for neurodegenerative diseases.
Skills the Lab Values
cell culturegenetic mutagenesismouse modelsmolecular biology techniquesquantitative proteomicsimmunohistochemistryWestern blotRNA sequencingautophagy assaysneuron imaging
Output against the department
Publications210top 35% of dept.233rd of 671
this lab
most publishedleast published
Citations42ktop 8% of dept.54th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.