RUThe Rockefeller University · Microbiology & Immunology
Rice Virology Lab
Charles M Rice · New York, New York
Research Focus
Dr. Charles M. Rice's research lab focuses on viral infections, particularly hepatitis B and various RNA viruses, including coronaviruses. The lab seeks to understand how these viruses interact with host cells, the mechanisms by which the immune system responds to these infections, and how viral pathogenesis occurs at the cellular level. By employing advanced technologies such as RNA sequencing and single-cell analysis, the lab aims to uncover new therapeutic strategies and improve our understanding of viral diseases.
hepatitis BcoronavirusRNA virusesviral pathogenesisepitranscriptomeimmune responseinterferonsingle-cell analysism5C modification
Research Aims
5AIM 01Investigate the antiviral mechanisms of interferon in hepatitis B virus infection.
AIM 02Explore the role of m5C RNA modification in viral life cycles and pathology.
AIM 03Develop single-cell approaches to study SARS-CoV-2 dynamics and host responses.
AIM 04Identify host factors that contribute to viral susceptibility and treatment outcomes.
AIM 05Unravel the mechanisms of flavivirus pathogenesis in the central nervous system.
Skills the Lab Values
Molecular cloningCell cultureRNA sequencingCRISPR gene editingHigh-throughput sequencingAnimal modelingFlow cytometryImmunohistochemistryComputational modeling
Output against the department
Publications719top 3% of dept.14th of 486
this lab
most publishedleast published
Citations102ktop 1% of dept.7th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.