New York University · BiochemistryArmache Lab
Karim Jean Armache · New York, New York
Research Focus
Karim Jean Armache's lab at NYU focuses on understanding how the addition of methyl groups to DNA (a process called DNA methylation) is altered in cancer. Specifically, they study a protein called DNMT3A1 that is important for adding these methyl groups and how its activity is regulated by different chemical modifications on histones, which are proteins that package DNA. By exploring these mechanisms, the lab aims to uncover new strategies for targeting cancer through epigenetic approaches, potentially leading to more effective and less toxic treatments.
DNA methylationcancer biologygene regulationepigeneticschromatin modification
Research Aims
4AIM 01Investigate how DNMT3A1 is regulated by histone modifications in normal and cancer cells.
AIM 02Understand the role of DNA methylation in silencing tumor suppressor genes in cancer.
AIM 03Explore the mechanisms by which aberrant methylation patterns arise in tumors.
AIM 04Develop therapeutic strategies to inhibit DNMT3A1 interactions for targeted cancer treatment.
Skills the Lab Values
PCRcell culturechromatin immunoprecipitationDNA sequencingcryoelectron microscopyorganoid culturebioinformaticsWestern blot
Output against the department
Publications66bottom 12% of dept.353rd of 402
this lab
most publishedleast published
Citations3.4kbottom 16% of dept.336th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.