University of California-San Francisco · PharmacologySurfaceome Dynamics Lab
James A Wells · San Francisco, California
Research Focus
Dr. James A. Wells' lab focuses on understanding the proteins on the surface of cells, known as the surfaceome. These proteins are crucial for how cells communicate and respond to their environment. By developing innovative technologies, his team aims to analyze small populations of cells at high resolution, particularly in the context of cancer and neurodegenerative diseases. Their goal is to identify new biomarkers and drug targets, as well as to create specific antibodies that can better modulate cell functions.
cell surface proteomesurfaceomicsantibodiesneurodegenerationcancerinteractomebiomarkersproteomicsadvanced technologies
Research Aims
5AIM 01Develop new technologies for analyzing the cell surfaceome.
AIM 02Characterize protein complexes on cell surfaces in health and disease.
AIM 03Identify biomarkers for cancer and neurodegenerative conditions.
AIM 04Create antibodies that modulate surface protein function.
AIM 05Investigate how changes in cell surface proteins influence cellular behavior.
Skills the Lab Values
cell cultureantibody developmenthigh-resolution imagingprotein purificationproximity labeling techniquesCRISPRrecombinant protein expressionimmunoassayssample preparation for proteomics
Output against the department
Publications593top 7% of dept.33rd of 462
this lab
most publishedleast published
Citations53ktop 4% of dept.18th of 462
this lab
most citedleast cited
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