University of Michigan-Ann Arbor · Biomedical EngineeringThe TumorWave Lab
Zhen Xu · Ann Arbor, Michigan
Research Focus
Dr. Zhen Xu's lab at the University of Michigan focuses on innovative ways to treat soft tissue sarcomas, which are challenging tumors to manage due to their size and location near critical structures. They are developing a new ultrasound-based system that can safely and effectively destroy these tumors without the need for surgery. This research aims to enhance patient outcomes by creating non-invasive treatment options that can potentially benefit both humans and animals.
ultrasoundsoft tissue sarcomahistotripsynon-invasive treatmenttumor ablation3D imagingrobotic assistancecavitationcancer therapy
Research Aims
3AIM 01Design and construct an integrated histotripsy system for 3D cavitation monitoring and treatment guidance.
AIM 02Optimize histotripsy treatment parameters for fast and safe applications in soft tissue.
AIM 03Test the safety and efficacy of the histotripsy system in canine soft tissue sarcoma patients.
Skills the Lab Values
ultrasound imaginghistotripsyroboticstissue sample handlinganimal modelscavitation monitoringcancer research methodologiesexperimental designdata collection
Output against the department
Publications277top 34% of dept.204th of 595
this lab
most publishedleast published
Citations9.6ktop 36% of dept.214th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.