University of Texas Southwestern Medical Center · Biomedical EngineeringAlluri Oncology Lab
Prasanna G Alluri · Dallas, Texas
Research Focus
Dr. Prasanna G Alluri's lab focuses on understanding and overcoming treatment resistance in breast cancer, specifically through targeting two proteins called CDK4 and CDK6. The team is investigating how these proteins contribute to tumor growth and resistance to therapies, aiming to develop new strategies to improve treatment outcomes for patients with estrogen receptor-positive breast cancer. Their research combines advanced genomic and machine learning techniques to explore how modifying the expression of CDK6 can help combat drug resistance in cancer cells.
breast cancerCDK4CDK6drug resistanceproteolysis targeting chimera (PROTAC)transcriptional reprogrammingendocrine therapypatient-derived xenografts (PDXs)
Research Aims
3AIM 01Define the roles of CDK6's kinase-dependent and kinase-independent functions in breast cancer drug resistance.
AIM 02Evaluate the effectiveness of a selective degraders targeting CDK4/6 in resistant breast cancer models.
AIM 03Assess the combined efficacy of CDK4/6-targeting agents with standard therapies in humanized mouse models.
Skills the Lab Values
cell culture3D genomic analysismachine learningxenograft modelspharmacological testingWestern blotRNA sequencingtumor growth evaluationmouse models
Output against the department
Publications95bottom 15% of dept.502nd of 595
this lab
most publishedleast published
Citations1.3kbottom 8% of dept.545th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.