Icahn School of Medicine at Mount Sinai · BiologyGhaffari Erythropoiesis Lab
Saghi Ghaffari · New York, New York
Research Focus
Dr. Saghi Ghaffari's lab at the Icahn School of Medicine focuses on understanding how certain cellular organelles, like mitochondria and lysosomes, play critical roles in blood cell development and leukemia. They explore how these organelles influence the maturation of red blood cells and the behavior of leukemic stem cells. By uncovering these mechanisms, the lab aims to develop new therapeutic strategies for blood disorders and leukemia.
mitochondriaerythropoiesisleukemic stem cellslysosomesquiescencered blood cell productioncellular metabolismdisease mechanismstherapeutic interventions
Research Aims
5AIM 01Investigate mitochondrial clearance in erythroid cell maturation versus enucleation.
AIM 02Analyze the role of mitochondrial network and morphology in erythroid cell regulation.
AIM 03Examine pyruvate-mediated pathways contributing to terminal erythropoiesis.
AIM 04Explore lysosomal heterogeneity in leukemic stem cells for targeted isolation and maintenance.
AIM 05Assess the impact of lysosomal modulation on leukemic stem cell metabolism.
Skills the Lab Values
cell culturemouse modelsconfocal imagingmetabolomicsRNA sequencinggene expression analysislysosomal activity assayspyruvate metabolism studiessuperresolution imaging
Output against the department
Publications163top 41% of dept.421st of 1,033
this lab
most publishedleast published
Citations7.2kbottom 49% of dept.524th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.