University of California-Berkeley · EngineeringVaccine Adjuvant Engineering Lab
Jay D Keasling · Berkeley, California
Research Focus
Dr. Jay D. Keasling's lab focuses on developing improved vaccines by designing better adjuvants, which are substances that enhance the immune response to vaccine antigens. The research combines synthetic biology techniques to engineer yeast for adjuvant production with systems immunology to understand how these adjuvants work at the molecular level. This interdisciplinary approach aims to create innovative solutions for preventing and treating diseases.
adjuvantsvaccinessynthetic biologyimmunologyyeast engineeringQS-21molecular structureimmune responsedisease prevention
Research Aims
3AIM 01Engineer yeast to produce adjuvants like QS-21 from simple sugars.
AIM 02Characterize the immunogenicity of engineered adjuvants in vitro and in vivo.
AIM 03Iteratively diversify the molecular structures of adjuvants using combinatorial synthetic biology approaches.
Skills the Lab Values
synthetic biologyyeast engineeringimmunogenicity profilingmolecular cloningcell cultureanalytical chemistrybioinformaticsPCRcombinatorial techniques
Output against the department
Publications846top 3% of dept.9th of 278
this lab
most publishedleast published
Citations67ktop 3% of dept.8th of 278
this lab
most citedleast cited
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