University of Colorado Boulder · ChemistryLuger Lab
Karolin Luger · Boulder, Colorado
Research Focus
Dr. Karolin Luger's research focuses on understanding how the protein PARP1 interacts with DNA and chromatin in cells, especially in the context of cancer treatment. By studying PARP1's structure and function, her lab aims to develop more effective drugs that can enhance cancer therapy, particularly for tumors with DNA repair deficiencies. Their work could lead to innovations in how these drugs are applied and how they work at the molecular level.
PARP1chromatinDNA repaircancer therapydrug development
Research Aims
5AIM 01Investigate how PARP1 interacts with damaged versus intact DNA in chromatin.
AIM 02Determine the role of HPF1 in PARP1 activity and drug binding.
AIM 03Explore structural differences of PARP1 in active conformations to improve drug design.
AIM 04Evaluate how PARylation affects chromatin remodeling and DNA repair.
AIM 05Develop assays for screening new selective PARP inhibitors.
Skills the Lab Values
cryoelectron microscopybiochemical assayscell cultureprotein purificationstructural biologymass spectrometrymolecular modelingDNA binding assays
Output against the department
Publications303top 37% of dept.81st of 216
this lab
most publishedleast published
Citations31ktop 13% of dept.29th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.