University of Michigan-Ann Arbor · BiologyThe Hepatic Insight Lab
Jiandie D Lin · Ann Arbor, Michigan
Research Focus
Dr. Jiandie D Lin's lab at the University of Michigan focuses on understanding metabolic liver diseases, especially nonalcoholic steatohepatitis (NASH), which is a serious condition that can lead to liver damage and other health issues. The lab investigates the cellular and molecular mechanisms that contribute to liver disease, how certain cell types like macrophages are involved, and explores innovative pathways that could lead to new treatments. Their research aims to uncover insights that could help in developing effective therapies for liver diseases related to obesity.
NASHliver diseasemacrophagescellular senescencemetabolic disorderssingle-cell RNA sequencinghepatocyte signalingdisease progressiontherapeutic targets
Research Aims
5AIM 01Investigate the role of anti-senescence signaling in liver disease progression.
AIM 02Explore the contribution of macrophages to NASH pathogenesis.
AIM 03Elucidate the mechanisms of TrkB-T1 signaling in hepatocyte injury.
AIM 04Assess the therapeutic potential of Neuregulin 4 in metabolic liver disease.
AIM 05Characterize the cellular responses and crosstalk in NASH-affected livers.
Skills the Lab Values
single-cell RNA sequencingcell culturemouse modelstranscriptomic analysisflow cytometryWestern blotgenetic engineeringimmunohistochemistryanimal handlingbiochemical assays
Output against the department
Publications155top 44% of dept.450th of 1,033
this lab
most publishedleast published
Citations35ktop 9% of dept.91st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.