UWMUniversity of Wisconsin-Madison · Biology
Bhattacharyya Lab
Anita Bhattacharyya · Madison, Wisconsin
Research Focus
Dr. Anita Bhattacharyya's lab at the University of Wisconsin-Madison focuses on understanding Down syndrome, a genetic condition that often leads to intellectual disabilities. The lab investigates how trisomy 21 affects brain development, specifically looking at neuronal formation and synaptic connections. By using innovative stem cell models, they aim to uncover the molecular mechanisms behind cognitive impairments in Down syndrome, which could inform future therapeutic strategies.
Down syndrometrisomy 21neurogenesissynaptogenesishuman induced pluripotent stem cellsneuronal developmentmolecular pathwaysintellectual disabilitybrain development
Research Aims
5AIM 01Identify how trisomy 21 alters neurogenesis during brain development.
AIM 02Characterize synaptic changes in neurons affected by Down syndrome.
AIM 03Build human iPSC models to study developmental processes in Down syndrome.
AIM 04Explore the molecular pathways disrupted in Down syndrome.
AIM 05Generate a cellular atlas of the prenatal cortex in Down syndrome.
Skills the Lab Values
cell cultureRNA sequencingtranscriptomicsmouse modelsstem cell differentiationWestern blotimmunofluorescence microscopydata analysis using Rbioinformaticsmolecular cloning
Output against the department
Publications115bottom 41% of dept.613th of 1,033
this lab
most publishedleast published
Citations4.9kbottom 37% of dept.646th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.