University of Pennsylvania · Biomedical EngineeringMach Neuroimaging Lab
Robert H Mach · Philadelphia, Pennsylvania
Research Focus
Dr. Robert H. Mach's lab at the University of Pennsylvania focuses on advancing our understanding of neurodegenerative diseases by developing advanced imaging techniques. In particular, the lab is working on creating new Positron Emission Tomography (PET) ligands that help visualize protein clumps associated with conditions like Parkinson's disease and frontotemporal dementia. Through collaborations with top universities, the lab aims to improve diagnostic methods and therapeutics for these critical neurological disorders.
PET imagingneurodegenerative diseasesalpha synucleintauopathiesradiotracer developmentParkinson's diseasefrontotemporal dementiaCNS imagingclinical researchmultisite collaboration
Research Aims
5AIM 01Develop PET ligands for imaging alpha synuclein proteinopathies
AIM 02Create radiotracers for 4R tau proteinopathies
AIM 03Investigate the role of proteinopathies in neurodegenerative disorders
AIM 04Enhance diagnostic capabilities for Parkinson's disease and frontotemporal dementia
AIM 05Conduct cross-validation studies in basic science and clinical research.
Skills the Lab Values
Positron Emission Tomography (PET)radiotracer developmentmedicinal chemistrychemical synthesisclinical imaging techniquesdata analysiscross-validation studiesneurobiology methodscollaborative research
Output against the department
Publications682top 9% of dept.53rd of 595
this lab
most publishedleast published
Citations18ktop 20% of dept.120th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.