Pennsylvania State University-Main Campus · ChemistryNucleosome Dynamics and Gene Regulation Lab
Tae-Hee Lee · University Park, Pennsylvania
Research Focus
Dr. Tae-Hee Lee's lab at Penn State focuses on understanding how DNA and histones interact within the nucleosome, which is key to gene regulation. The lab employs cutting-edge single-molecule fluorescence techniques to study these interactions and how chromatin modifications influence gene accessibility. Their work has implications for understanding developmental issues and diseases, especially cancers.
DNA-histone interactionsnucleosome dynamicsgene regulationchromatin modificationssingle-molecule fluorescencecancer researchepigenetics
Research Aims
5AIM 01Elucidate the role of chromatin modifications on nucleosome structure.
AIM 02Investigate the dynamics of nucleosome interactions with histone variants.
AIM 03Explore the mechanisms through which RNA polymerase II affects nucleosome dynamics.
AIM 04Analyze the effects of histone acetylation and methylation on gene accessibility.
AIM 05Develop new single-molecule techniques to study nucleosome arrangements.
Skills the Lab Values
single-molecule fluorescenceFRETchromatin assaysnucleosome preparationoptical super-resolution microscopydata analysis with Pythonprotein purificationmolecular biology techniquesadvanced microscopyenzyme kinetics
Output against the department
Publications577top 14% of dept.31st of 216
this lab
most publishedleast published
Citations12ktop 42% of dept.91st of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.