Yale University · ChemistryCenter for Cancer and Antimicrobial Therapeutics
Seth B. Herzon · New Haven, Connecticut
Research Focus
Dr. Seth B. Herzon's lab at Yale University focuses on understanding and developing new treatments for cancer and drug-resistant bacterial infections. The research combines organic chemistry with biology to analyze the structures and functions of natural products and synthetic compounds, aiming to create novel therapeutics for targeted therapy. By exploring both the molecular mechanisms of these substances and their clinical applications, the lab seeks to address significant health challenges in oncology and antimicrobial resistance.
antimicrobialcancer therapynatural productssynthetic biologycolibactindrug resistanceDNA repairglycosylationbioactive metabolitestargeted therapeutics
Research Aims
5AIM 01Develop new synthetic methods to create potential anticancer agents.
AIM 02Elucidate the structure and function of colibactin and its role in colorectal cancer.
AIM 03Investigate novel antibiotics to combat drug-resistant bacterial infections.
AIM 04Create selective alkylation agents targeting cancer cells more effectively.
AIM 05Understand the mechanism of action for bioactive natural products in cancer therapy.
Skills the Lab Values
chemical synthesisstructural analysisbioassaysmurine modelsmass spectrometrycrystallographyspectroscopic methodsDNA interaction studiescollaborative research methodsapplication of organic chemistry
Output against the department
Publications225top 49% of dept.105th of 216
this lab
most publishedleast published
Citations5.4kbottom 38% of dept.133rd of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.