Icahn School of Medicine at Mount Sinai · Microbiology & ImmunologyFlavivirus Immune Evasion Laboratory
Matthew J Evans · New York, New York
Research Focus
Dr. Matthew J. Evans' lab at the Icahn School of Medicine focuses on understanding how certain viruses, particularly flaviviruses like Zika and dengue, evade the human immune system. By studying the nonstructural protein 5 (NS5) of these viruses, the lab aims to reveal mechanisms of viral replication and immune suppression. This knowledge is crucial for developing new antiviral treatments and vaccines.
Zika virusflavivirusimmune evasioninterferon signalingantiviral therapyviral proteinsSTAT2mutagenesisvaccine design
Research Aims
3AIM 01Examine how Zika virus NS5 suppresses interferon signaling through specific amino acids.
AIM 02Identify the influence of host genetics on NS5's ability to mediate infection.
AIM 03Determine the mechanisms by which NS5 leads to the degradation of STAT2.
Skills the Lab Values
deep mutational scanningcell cultureCRISPR screeningmolecular cloningprotein expressionviral infection assaysWestern blottingubiquitination analysisgenomic library designbioinformatics
Output against the department
Publications276top 19% of dept.89th of 486
this lab
most publishedleast published
Citations39ktop 6% of dept.30th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.