University of Texas Southwestern Medical Center · PharmacologyCenter for Bacterial Signaling and Resistance
Boyuan Wang · Dallas, Texas
Research Focus
Boyuan Wang's research lab at UT Southwestern Medical Center explores how bacteria communicate and respond to stress through a molecule called (p)ppGpp. This molecule helps bacteria survive antibiotics by halting their growth. The lab focuses on understanding the role of enzymes that degrade (p)ppGpp and how metal stress from the human body affects these enzymes. The ultimate goal is to discover new treatment methods to combat persistent bacterial infections.
bacterial signalingpGpp regulationhydrolasesantibiotic resistancemetal stressenzymatic mechanismsbacterial persistencetherapeutic targets
Research Aims
5AIM 01Elucidate the catalytic mechanisms of (p)ppGpp hydrolases.
AIM 02Investigate how metal stress impacts (p)ppGpp degradation.
AIM 03Explore the therapeutic potential of hydrolase inhibition.
AIM 04Understand bacterial persistence mechanisms during infections.
AIM 05Identify bacterial vulnerabilities to combat antibiotic resistance.
Skills the Lab Values
X-ray crystallographybacterial geneticsstructural biologybiochemistry techniquesenzyme kineticsin vitro studiesin vivo modelsdata analysisantibiotic testing
Output against the department
Publications137bottom 39% of dept.283rd of 462
this lab
most publishedleast published
Citations2.9kbottom 21% of dept.364th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.