University of Florida · PharmacologyNettles Hormone Lab
Kendall W Nettles · Gainesville, Florida
Research Focus
Dr. Kendall Nettles' lab at the University of Florida studies how hormones like estrogen and cortisol affect cancer and bodily responses to stress. They are working on developing new therapies for breast cancer that can overcome drug resistance and also on improving synthetic glucocorticoids to minimize side effects like muscle atrophy and insulin resistance. By understanding the molecular mechanisms involved, their goal is to create targeted treatments that are more effective and less harmful.
estrogen receptorglucocorticoidsbreast cancertumor resistancestress response hormone
Research Aims
5AIM 01Understand how different estrogen receptor ligands interact with breast cancer cells.
AIM 02Identify the molecular mechanisms behind glucocorticoid receptor signaling.
AIM 03Develop new synthetic glucocorticoids with reduced side effects.
AIM 04Analyze the structural differences that affect receptor activity across tissues.
AIM 05Examine the impact of hormone signaling on stem cell differentiation and inflammation.
Skills the Lab Values
cell cultureWestern blotChIP-seqconfocal microscopysmall animal modelsligand designmachine learningstructural biologychemical synthesistranscriptional regulation
Output against the department
Publications180bottom 49% of dept.231st of 462
this lab
most publishedleast published
Citations3.9kbottom 30% of dept.325th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.