Yale University · PharmacologyNeutrophil and Lipid Research Lab
Dianqing Wu · New Haven, Connecticut
Research Focus
Dr. Dianqing Wu's research lab at Yale University focuses on understanding the roles of neutrophils and their interaction with polyunsaturated fatty acids (PUFAs) in inflammation and heart health. The lab investigates novel mechanisms of lipid transport and signaling in immune cells, particularly looking at how these processes contribute to diseases like myocardial infarction and cancer. The insights gained aim to uncover potential therapeutic targets for treating inflammatory diseases and enhancing cancer immunotherapy.
neutrophilspolyunsaturated fatty acidslipid transportinflammationtumor immunityNK cellsimmunotherapyheart diseasessignal transduction
Research Aims
5AIM 01Investigate the role of LRP5 in neutrophil activation
AIM 02Characterize how LRP5 transports polyunsaturated fatty acids
AIM 03Determine the impact of PUFAs on mTORC1 signaling in neutrophils
AIM 04Explore the mechanism of LRP5 in regulating NK cell activities
AIM 05Assess the implications of LRP5 in tumor immunity and cancer progression.
Skills the Lab Values
cell culturemouse modelsKO (knockout) techniquesin vitro assaysflow cytometrymolecular biology techniquesWestern blotimmunohistochemistrylipidomicsproteomics
Output against the department
Publications80bottom 18% of dept.376th of 462
this lab
most publishedleast published
Citations14ktop 29% of dept.132nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.