University of Kentucky · PhysiologyCenter for Calcium Channel Research
Jonathan Satin · Lexington, Kentucky
Research Focus
Dr. Jonathan Satin's lab at the University of Kentucky focuses on understanding how calcium channels in heart cells can be regulated to improve heart function, especially in cases of heart failure. The lab investigates the signaling pathways that control these channels, aiming to find safer ways to enhance heart contractions without the negative effects associated with current treatments. Their research combines genetic models and pharmacological approaches to explore how specific proteins affect heart health and disease.
L-type Calcium ChannelsHeart HealthHeart FailureCa2+ SignalingRegulatory ProteinsGenetic ModelsInotropic SupportSignal Transduction
Research Aims
3AIM 01Dissect how RAD integrates signaling pathways that regulate calcium channels.
AIM 02Explore the structure-function relationship of RAD and calcium channels using genetically modified mice.
AIM 03Investigate the role of RAD in attenuating heart failure progression.
Skills the Lab Values
Cell CultureMolecular CloningMouse ModelsElectrophysiologyCRISPR Gene EditingProtein PurificationWestern BlottingConfocal Microscopy
Output against the department
Publications106bottom 31% of dept.195th of 286
this lab
most publishedleast published
Citations4.7kbottom 41% of dept.170th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.