Baylor College of Medicine · BiologyThe NeuroGenesis Lab
Ronald J Parchem · Houston, Texas
Research Focus
The lab of Dr. Ronald J. Parchem at Baylor College of Medicine focuses on understanding how certain microRNAs influence brain development, particularly in relation to congenital hydrocephalus. By studying the MIR302 family of microRNAs, the lab investigates the timing and regulation of neural stem cell differentiation, which is crucial for proper brain structure formation. This research aims to uncover the molecular mechanisms underlying neurodevelopmental disorders and could lead to new therapeutic approaches for brain malformations.
microRNAsneurodevelopmentcongenital hydrocephalusneural differentiationepigenetics
Research Aims
5AIM 01Define how miR-302 functions as a post-transcriptional regulator.
AIM 02Examine how distinct MIR302 members modulate chromatin accessibility.
AIM 03Investigate the epigenetic mechanisms involved in congenital hydrocephalus.
AIM 04Link aberrant gene expression to the loss of miR-302.
AIM 05Reveal why the subcommissural organ is susceptible to timing defects.
Skills the Lab Values
RNA sequencingchromatin accessibility assayssingle-nuclei RNA-seqmolecular cloningmouse modelsco-immunoprecipitationdata analysisbioinformaticstranslational regulation
Output against the department
Publications41bottom 8% of dept.947th of 1,033
this lab
most publishedleast published
Citations742bottom 3% of dept.1,000th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.