University of Michigan-Ann Arbor · BiochemistryMorrissey Lab
James H. Morrissey · Ann Arbor, Michigan
Research Focus
Dr. James H. Morrissey’s lab at the University of Michigan focuses on understanding the complex mechanisms behind blood clotting, particularly how certain molecules can cause harmful blood clots leading to conditions like heart attacks and strokes. The research aims to differentiate between normal blood clotting processes and those that result in disease, offering insights that could lead to new treatments for thrombotic disorders. Through exploring aspects such as tissue factor interaction and procoagulant polymers, this lab contributes to improving public health outcomes related to clotting disorders.
blood clottingthrombosishemostasisimmunothrombosispolyphosphateDAMPsPAMPsvascular injury
Research Aims
5AIM 01Investigate how procoagulant anionic polymers like polyP influence blood clotting
AIM 02Examine the structural details of the tissue factor/factor VIIa complex
AIM 03Understand the role of phospholipid bilayers in regulating blood coagulation
AIM 04Identify therapeutic targets in thrombotic disease mechanisms
AIM 05Differentiate between hemostatic processes and pathological thrombosis
Skills the Lab Values
PCRcell culturemouse modelsWestern blotflow cytometrymolecular cloningprotein purificationenzyme assayslipid bilayer analysis
Output against the department
Publications370top 14% of dept.58th of 402
this lab
most publishedleast published
Citations23ktop 17% of dept.69th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.