University of Rochester · BiochemistryIntegrative Neurobiology Lab
Eric J Wagner · Rochester, New York
Research Focus
Dr. Eric Wagner's lab at the University of Rochester focuses on understanding how the Integrator Complex, a group of proteins involved in gene regulation, affects the function of neurons. By studying how specific proteins interact within this complex, the lab aims to uncover the molecular mechanisms that regulate neuronal development and function, particularly in the context of neurological disorders. The research holds promise for insights that could improve health outcomes and tackle brain-related diseases.
RNA polymerase IIgene regulationneurodevelopmentneural cellsIntegrator Complexneurodegenerationbiochemical characterizationcell fitnessCRYO-EMtranscription regulation
Research Aims
3AIM 01Characterize the INTS9, INTS11, BRAT1, and WDR73 protein complexes biochemically and structurally.
AIM 02Investigate the role of BRAT1 and WDR73 in regulating gene expression through the Integrator Complex.
AIM 03Examine the functions of INTS11-containing complexes in neuronal cells.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)biochemical assaysprotein purificationgenetic analysiscell culturestructural biology techniquesmolecular cloningtranscription factor analysisRNA extractionimmunoprecipitation
Output against the department
Publications267top 25% of dept.102nd of 402
this lab
most publishedleast published
Citations12ktop 42% of dept.170th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.