AECAlbert Einstein College of Medicine · Biology
Tet2 Research Lab
Keisuke Ito · Bronx, New York
Research Focus
Dr. Keisuke Ito's lab focuses on understanding the role of the Tet2 gene in hematopoietic stem cells, which are essential for producing blood cells. They study how mutations in Tet2 can lead to disorders like myelodysplastic syndrome (MDS), a disease where blood production is impaired. By using genetically modified mouse models, the lab aims to uncover the molecular mechanisms by which Tet2 functions, contributing to better treatments for blood-related diseases.
Tet2hematopoietic stem cellsmyelodysplastic syndromegene regulationDNA methylation
Research Aims
4AIM 01Define non-catalytic functions of Tet2 in hematopoietic stem cell self-renewal and differentiation.
AIM 02Investigate how non-catalytic functions of human TET2 prevent myelodysplastic syndrome.
AIM 03Establish Tet2's role in DNA methylation landscape regulation over time.
AIM 04Explore Tet2's non-catalytic regulatory partnerships for gene suppression and activation.
Skills the Lab Values
mouse modelsgenetic modificationepigenomic analysistranscriptomic analysisflow cytometry
Output against the department
Publications452top 9% of dept.98th of 1,033
this lab
most publishedleast published
Citations18ktop 22% of dept.229th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.