University of California-Berkeley · BiochemistryCellular Interaction Laboratory
David G Drubin · Berkeley, California
Research Focus
David G Drubin's lab at UC Berkeley focuses on understanding how cells take in materials and interact with their environment, particularly through a process called clathrin-mediated endocytosis (CME). They study this process in both yeast and human stem cells, using advanced imaging techniques to look at the proteins involved and how they function together. Their research aims to uncover the mechanisms behind how cells differentiate and respond under various conditions, which could have implications for understanding diseases and developing treatments.
clathrin-mediated endocytosisactin assemblyyeasthuman stem cellscell physiologycell differentiationprotein recruitmentmembrane curvatureCOVID-19cellular processes
Research Aims
4AIM 01Investigate how membrane curvature affects biochemical reaction rates during CME.
AIM 02Explore how CME specialization occurs in different cell types during differentiation.
AIM 03Determine how a checkpoint senses cargo to regulate CME progress.
AIM 04Examine the assembly of actin at CME sites and its role in force production and membrane tension adaptation.
Skills the Lab Values
cell culturefluorescence imaginggenome editinglive cell imagingprotein purificationmicroscopyyeast geneticsbiochemical assaysactin cytoskeleton analysistissue culture
Output against the department
Publications318top 19% of dept.78th of 402
this lab
most publishedleast published
Citations31ktop 12% of dept.47th of 402
this lab
most citedleast cited
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