Binghamton University · PsychologyHippocampal Vascular Health Lab
Abbie C Chapman · Vestal, New York
Research Focus
Dr. Abbie C. Chapman's lab focuses on understanding how chronic hypertension affects brain blood vessels, particularly in the hippocampus, which is crucial for memory and learning. By studying the arterioles that supply blood to this brain region, the lab aims to uncover how vascular health impacts cognitive decline and dementia. The research combines animal models with experimental techniques to explore these relationships and identify potential therapeutic approaches to preserve cognitive function as the brain ages.
vascular cognitive impairmentdementiahypertensionhippocampusneurovascular couplingcognitive declineaged modelssex differencesblood flow regulationmemory function
Research Aims
5AIM 01Investigate the vasodilatory and vasoconstrictive functions of hippocampal arterioles in hypertensive and normotensive rats.
AIM 02Analyze the relationship between hippocampal perfusion and cognitive function in aged rats subjected to chronic hypertension.
AIM 03Examine sex differences in hippocampal vascular responses during aging and hypertension.
AIM 04Determine the effects of improving arteriolar function on preserving hippocampal neuronal integrity and cognitive abilities.
AIM 05Explore the underlying mechanisms of oxidative stress in contributing to arteriolar dysfunction related to hypertension.
Skills the Lab Values
cell culturerat modelsin vitro studiesmicrovascular assessmentimmunohistochemistryneurobehavioral testingpressure myographydata analysisstatistical modelingexperimental design
Output against the department
Publications14bottom 1% of dept.292nd of 296
this lab
most publishedleast published
Citations272bottom 2% of dept.290th of 296
this lab
most citedleast cited
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