Baylor College of Medicine · BiologyAHR Discovery Lab
Daniel Gorelick · Houston, Texas
Research Focus
Dr. Daniel Gorelick's lab at Baylor College of Medicine studies how environmental pollutants like dioxins and polycyclic aromatic hydrocarbons (PAHs) affect health by interacting with proteins in our cells. They focus on a specific protein called the aryl hydrocarbon receptor (AHR) that regulates gene expression in response to these toxic substances. By exploring the complexities of AHR signaling, the lab aims to uncover new insights into how these pollutants can lead to diseases, thereby improving our understanding of their impact on human health.
Aryl Hydrocarbon ReceptorToxicityEnvironmental PollutantsGene ExpressionTranscription FactorsDioxinsPolycyclic Aromatic HydrocarbonsCell Biology
Research Aims
3AIM 01Investigate how different ligands influence the activity of the aryl hydrocarbon receptor.
AIM 02Determine the role of non-consensus DNA sequences in AHR signaling and gene regulation.
AIM 03Explore the impact of ARNT1 and ARNT2 proteins on AHR's ability to bind DNA in vivo.
Skills the Lab Values
Chromatin Immunoprecipitation (ChIP)Molecular CloningDNA SequencingCell CultureMouse ModelsZebrafish ModelsBiochemical AssaysGene Expression AnalysisElectrophoretic Mobility Shift Assay (EMSA)Transcription Factor Binding Studies
Output against the department
Publications59bottom 15% of dept.878th of 1,033
this lab
most publishedleast published
Citations1.3kbottom 7% of dept.957th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.