Ohio State University-Main Campus · NeuroscienceThe NeuroRegeneration Lab
Giles Plant · Columbus, Ohio
Research Focus
Dr. Giles Plant's research focuses on finding innovative ways to repair cervical spinal cord injuries using human neurons derived from induced pluripotent stem cells (iPSCs). His lab develops and tests transplantation strategies where these neurons are integrated into injured spinal cords, aiming to restore motor function and improve the quality of life for patients. By studying how these transplanted neurons form connections and integrate into existing neural circuits, the lab seeks to make significant advances in regenerative therapies for spinal injuries.
human iPSC neuronscervical spinal cord injuryneural transplantationneuroregenerationmotor functionneuronal circuits
Research Aims
5AIM 01Develop a robust method for inducing human iPSCs into deep cortical neurons.
AIM 02Evaluate the survival and integration of transplanted neurons in a spinal cord injury model.
AIM 03Assess functional recovery of upper limb movement in animal models after neuron transplantation.
AIM 04Investigate synaptic connectivity between host spinal cord and transplanted neurons.
AIM 05Test behavioral outcomes in subjects following therapeutic interventions for spinal cord injury.
Skills the Lab Values
cell culturetissue engineeringanimal modelsneuroscience techniquesfunctional assaysimmunohistochemistry
Output against the department
Publications95bottom 31% of dept.461st of 671
this lab
most publishedleast published
Citations4.2kbottom 32% of dept.457th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.