Harvard University · BiochemistryCellular Signaling Dynamics Lab
Stephen C. Blacklow · Cambridge, Massachusetts
Research Focus
Dr. Stephen C. Blacklow's lab at Harvard Medical School focuses on understanding the molecular mechanisms of cellular signaling, particularly through Notch signaling and tetraspanin proteins. They employ advanced technologies to visualize how signals are transmitted within cells, which is important for understanding diseases like cancer and immune disorders. The lab's research aims to pave the way for future therapeutic strategies by elucidating the roles of these signaling pathways in both normal physiology and disease states.
Notch signalingtetraspaninssignal transductionB cell receptorADAM10cell differentiationproximity labelinglight sheet microscopy
Research Aims
5AIM 01Investigate the intracellular dynamics of Notch signaling in real time.
AIM 02Elucidate the molecular mechanisms by which tetraspanins regulate B cell receptor signaling.
AIM 03Characterize the role of tetraspanins in modulating ADAM10 metalloprotease function.
AIM 04Develop computational tools for visualizing cellular signaling events.
AIM 05Apply proximity labeling techniques to enhance understanding of protein interactions.
Skills the Lab Values
cell cultureCRISPRmass spectrometrylattice light sheet microscopyprotein purificationbiochemical assaysstructural biology techniquesimaging technologiesmolecular dynamics simulations
Output against the department
Publications293top 22% of dept.90th of 402
this lab
most publishedleast published
Citations23ktop 18% of dept.72nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.