Icahn School of Medicine at Mount Sinai · Microbiology & ImmunologyViral Dynamics and Host Interactions Lab
Jeffrey R Johnson · New York, New York
Research Focus
Dr. Jeffrey R. Johnson's lab focuses on understanding how viruses like HIV-1 and SARS-CoV-2 manipulate human cells during infection. The research aims to uncover the mechanisms by which these viruses degrade host proteins to enhance their replication and to identify potential therapeutic targets for treating viral infections. Through various molecular and genetic techniques, the lab strives to advance our understanding of viral biology and contribute to the development of new antiviral therapies.
HIV-1SARS-CoV-2protein degradationMAPK pathwaysCRISPRviral replicationantiretroviral therapysignal transductionproteomics
Research Aims
5AIM 01Investigate the cellular determinants of PP2A-B56 degradation by HIV-1 Vif.
AIM 02Define the functional consequences of PP2A-B56 degradation on HIV-1 fitness.
AIM 03Examine how MAPK pathways facilitate SARS-CoV-2 replication in host cells.
AIM 04Explore potential MAPK inhibitors as treatment options for COVID-19.
AIM 05Identify alternative targets within the MAPK family to aid in antiviral strategies.
Skills the Lab Values
CRISPR/Cas9 gene editingprotein interaction assaysgenetic screeningcell cultureflow cytometryproteomics techniquesin vivo modelsex vivo modelsphosphorylation analysisantiviral drug development
Output against the department
Publications655top 3% of dept.17th of 486
this lab
most publishedleast published
Citations28ktop 12% of dept.56th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.