University of California-Irvine · PhysiologyQin Diabetes Lab
Qin Yang · Irvine, California
Research Focus
Dr. Qin Yang's lab at the University of California-Irvine focuses on understanding how genetic factors contribute to type 2 diabetes, particularly through mechanisms like alternative polyadenylation. By studying specific genes and their regulation, the lab aims to uncover how these processes affect insulin production and function in pancreatic cells. This research not only elucidates basic biological mechanisms but also seeks to improve diabetes prevention strategies for individuals at genetic risk.
diabetesalternative polyadenylationinsulin resistancegenetic predispositionepitranscriptomics
Research Aims
3AIM 01Identify causal SNPs impacting alternative polyadenylation of ZC3H13.
AIM 02Determine mechanisms by which 3'UTR lengthening reduces ZC3H13 protein expression.
AIM 03Investigate how reduced ZC3H13 expression impairs insulin production and islet function.
Skills the Lab Values
CRISPR/Cas technologyRNA sequencingcell culturegene expression analysismouse genetics
Output against the department
Publications417top 9% of dept.26th of 286
this lab
most publishedleast published
Citations5.3kbottom 45% of dept.158th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.