MUSMedical University of South Carolina · Pharmacology
Wang Immunotherapy Lab
Haizhen Wang · Charleston, South Carolina
Research Focus
Dr. Haizhen Wang's lab at the Medical University of South Carolina focuses on improving immunotherapy for solid tumors by studying the functions of cyclin D proteins in T cells. The lab investigates how these proteins impact T cell survival and their ability to infiltrate tumors, which are critical for effective cancer treatment. By manipulating cyclin D expression, the research aims to enhance the efficacy of T cell therapies against cancers like melanoma and colorectal cancer.
T cell infiltrationimmunotherapycyclin Dtumor microenvironmentcancer progressioncholesterol homeostasissolid tumorsadoptive T-cell therapy
Research Aims
3AIM 01Investigate how cyclin D3 influences cholesterol levels to regulate T-cell survival in tumors.
AIM 02Determine the role of cyclin D3 in the expression of adhesion proteins affecting T-cell infiltration.
AIM 03Evaluate the effectiveness of modified T cells with altered cyclin D expression against melanoma and colon cancers.
Skills the Lab Values
cell cultureRNA sequencingin vivo studiesgene expression analysisprotein expression assaysflow cytometryWestern blotmouse modelsCRISPR
Output against the department
Publications184top 48% of dept.223rd of 462
this lab
most publishedleast published
Citations5.7kbottom 41% of dept.272nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.