University of California-Los Angeles · Chemistry3D Organ Imaging Lab
Roy Wollman · Los Angeles, California
Research Focus
Dr. Roy Wollman's lab at UCLA focuses on innovating methods to study the anatomy and function of organs using advanced imaging techniques. The lab is developing a groundbreaking approach called dredFISH, which allows researchers to map the gene expression of entire organs in 3D, moving beyond traditional 2D techniques. By creating detailed atlases of cell types and gene expression, this research has the potential to transform our understanding of biological structures and their functions.
spatial transcriptomicswhole organ mappingdimensionality reductionfluorescent in situ hybridizationgene expression atlas3D imaginglight-sheet microscopycell type classificationmouse brain
Research Aims
3AIM 01Develop a method for whole organ spatial transcriptomics using dredFISH.
AIM 02Optimize dredFISH for 2D samples to facilitate 3D application.
AIM 03Create cell type and gene expression atlases for the entire mouse brain.
Skills the Lab Values
Fluorescent In Situ Hybridization (FISH)Light-sheet microscopyTissue clearing techniquesHydrogel embeddingRNA sequence data analysisImaging protocol developmentExperimental designData interpretationTissue sectioning techniques
Output against the department
Publications79bottom 15% of dept.182nd of 216
this lab
most publishedleast published
Citations4.7kbottom 36% of dept.139th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.