Tufts University · BiochemistryOlfactory Aging Research Unit
Brian Lin · Medford, Massachusetts
Research Focus
Dr. Brian Lin's research lab at Tufts University focuses on understanding how our sense of smell declines with age. They have developed a new model that mimics accelerated aging in the olfactory epithelium, which could pave the way for finding treatments for age-related smell disorders like anosmia. The lab aims to explore the mechanisms behind this decline and test potential therapies to restore olfactory function.
olfactory dysfunctionagingneurogenesisstem cellsanosmiapreclinical modelsrespiratory metaplasiatherapeutic interventionsengineered enzymes
Research Aims
3AIM 01Characterize the new model of accelerated aging in the olfactory epithelium.
AIM 02Investigate the hypothesis that respiratory metaplasia results from stem cell exhaustion.
AIM 03Test targeted therapeutic approaches developed from insights into olfactory epithelial dynamics.
Skills the Lab Values
cell culturemouse modelsbiopsy analysisgenetic engineeringimmunohistochemistryRNA sequencingflow cytometrybehavioral assaysdata analysis in R
Output against the department
Publications69bottom 13% of dept.348th of 402
this lab
most publishedleast published
Citations7.2kbottom 39% of dept.246th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.