University of California-Irvine · BiochemistryAmyloid Dynamics Research Lab
Charles G. Glabe · Irvine, California
Research Focus
Dr. Charles G. Glabe's lab at UC Irvine focuses on understanding the formation and dynamics of amyloid plaques, a key feature of Alzheimer's disease. The research aims to investigate how different types of amyloid deposits are formed by various cell types and their roles in the progression of the disease. By using innovative labeling techniques to track proteins in real-time, the lab hopes to uncover new insights that could guide the development of better therapies for Alzheimer's.
Alzheimer's diseaseamyloid plaquesbiorthogonal technologycellular dynamicsprotein labelingtherapeutic developmentCre driver technologyneurodegenerationamyloid deposition
Research Aims
5AIM 01Investigate the temporal and spatial dynamics of amyloid plaque deposition.
AIM 02Identify the different mechanisms by which various types of amyloid plaques are formed.
AIM 03Explore the contributions of specific cell types to amyloid deposition.
AIM 04Understand the relationships between amyloid plaques and Alzheimer's disease pathogenesis.
AIM 05Develop effective strategies for targeted therapies based on plaque formation insights.
Skills the Lab Values
biochemical analysisclick chemistryprotein purificationmouse modelingfluorescence microscopyCre-lox recombinationMolecular Biology techniquesazidonorleucine labelingimmunohistochemistry
Output against the department
Publications249top 30% of dept.120th of 402
this lab
most publishedleast published
Citations37ktop 7% of dept.28th of 402
this lab
most citedleast cited
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