Augusta University · NeuroscienceLu Neuroinflammation Lab
Xin-Yun Lu · Augusta, Georgia
Research Focus
Dr. Xin-Yun Lu's lab at Augusta University focuses on understanding the mechanisms of Alzheimer's disease (AD) and the effects of aging and chronic stress on brain health. The research investigates how specific neurons respond to stress and aging, and how inflammation in the brain can affect cognitive function over time. By exploring factors like HDAC9 and the Duffy Antigen Receptor for Chemokines (DARC), the lab aims to uncover therapeutic targets to help combat cognitive decline associated with Alzheimer’s disease.
Alzheimer's diseasechronic stressbrain agingneuroinflammationAgRP neuronsDARCHDAC9cognitive declinesynaptic plasticityepigenetics
Research Aims
3AIM 01Identify molecular mechanisms leading to silencing of AgRP neurons during chronic stress and aging.
AIM 02Determine the impact of AgRP neuron activity on HPA axis dysregulation and Alzheimer’s pathology.
AIM 03Investigate how DARC influences neuroinflammation and cognitive decline related to aging and Alzheimer's disease.
Skills the Lab Values
mouse modelsneuron culturebehavioral assaysmolecular cloningbiochemical assaysinflammation assaysimmunohistochemistryWestern blotRNA sequencinggenetic engineering
Output against the department
Publications89bottom 28% of dept.479th of 671
this lab
most publishedleast published
Citations5.7kbottom 41% of dept.399th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.