Northwestern University · PharmacologyThe Protein Stability Lab
Gabriel Jacob Rocklin · Evanston, Illinois
Research Focus
Dr. Rocklin's lab focuses on understanding how proteins fold and remain stable, which is critical for their functions in biological systems. They develop innovative methods to measure the stability of thousands of proteins at once. This research can lead to enhancements in drug and vaccine development by predicting how genetic variations affect protein behavior and by creating smart models to guide these processes.
protein stabilitymachine learningfolding energy landscapesdrug developmentvaccine developmentprecision medicinedata analysisexperimental methods
Research Aims
5AIM 01Measure global folding stability of millions of protein sequences.
AIM 02Analyze folding energy landscapes for thousands of different proteins.
AIM 03Develop machine learning models to predict protein stability.
AIM 04Enhance understanding of genetic variants on protein stability.
AIM 05Generate large datasets to empower future research in drug and vaccine development.
Skills the Lab Values
high-throughput screeningmachine learning model developmentprotein engineeringdata collectionexperimental designbioinformaticsstatistical analysismass spectrometrycomputational modeling
Output against the department
Publications1bottom 1% of dept.460th of 462
this lab
most publishedleast published
Citations0bottom 1% of dept.461st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.